Volume 3, 2022



Dimitar Ribov
Pages: 114-118

ABSTRACT: A clinical case is presented of a 60-year-old man with thrombotic thrombocytopenic purpura that occured after surgical treatment of a patellar fracture and long-term administration of fraxiparin. The purpose of the presentation is to give more information about a rare nosological entity that represents an emergency in hematology and is almost always fatal if proper treatment is not started immediately. It is a form of thrombotic thrombocytopenia, characterized by greatly reduced ADAMTS13 protease activity which removes the von Willebrand factor. It represents a heterogeneous syndrome with a classic presentation of thrombocytopenia, Coombs negative hemolytic anemia, fever, neurologic symptoms and renal failure.


Keywords: thrombotic microangiopathy, thrombotic thrombocytopenic purpura, clinical case


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