TROMBOTIC THROMBOCYTOPENIC PURPURA CLINICAL CASE REPORT
ABSTRACT: A clinical case is presented of a 60-year-old man with thrombotic thrombocytopenic purpura that occured after surgical treatment of a patellar fracture and long-term administration of fraxiparin.
The purpose of the presentation is to give more information about a rare nosological entity that represents an emergency in hematology and is almost always fatal if proper treatment is not started immediately. It is a form of thrombotic thrombocytopenia, characterized by greatly reduced ADAMTS13 protease activity which removes the von Willebrand factor. It represents a heterogeneous syndrome with a classic presentation of thrombocytopenia, Coombs negative hemolytic anemia, fever, neurologic symptoms and renal failure.
Keywords: thrombotic microangiopathy, thrombotic thrombocytopenic purpura, clinical case